Since turning professional in 1992, John Senden has played all over the world. He is a regular competitor on the PGA Tour of Australasia and has spent time playing in Asia. In Europe he won twice on the second tier Challenge Tour in 1998 and was a member of the main European Tour from 1999 to 2001. In 2002 he joined the PGA Tour and four years later claimed his first US title at the John Deere Classic. Later that year he claimed his first Australian title, the Australian Open.
- 2005 Finished in the top 100 on the PGA Tour money list for the first time in his career
- 2006 Claimed his first PGA TOUR victory in 139th career TOUR start at the John Deere Classic. In doing so he became the fifth Aussie to win on the Tour in that year
- 2006 Recorded a hole-in-one on the par-3 13th hole at Royal Liverpool Golf Club during third round of the British Open, finished T35
- 2006 Represented Australia in the World Cup
- 2007 Finished as the leading Australian at the US PGA Championship (T4)
- 2007 Reached the top 50 of the Official World Golf Rankings for the first time
- 2011 Turned in a consistent year on the PGA TOUR after making 20 of 26 cuts and recording a career-best 14 top-25 finishes